Urinary excretion of furosemide in rats with HgCl sub 2 -induced acute renal damage

Journal Article · Tue Dec 31 23:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(92)90560-C· OSTI ID:6952265

Fujimura, Akio; Sudoh, Toshiaki; Ohashi, Kyoichi; Ebihara, Akio ^[1]

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1. Jichi Medical School, Tochigi (Japan)

To examine the influence of mercuric chloride (HgCl{sub 2})-induced acute renal damage on urinary excretion of furosemide, HgCl{sub 2} or its vehicle along was given intraperitoneally to Wistar rats. The following two experiments were done. Study 1: three percent body weight (b.w.) of 1% NaCl solution or furosemide in 3% b.w. of 1% NaCl solution was given orally before and after HgCl{sub 2} treatment, and an 8-hour urine was collected. Study 2: furosemide was given orally, and blood samples were obtained at 1, 2, 3, 4, 6 and 8 hours after administration. Urinary excretion of N-acetyl-{beta}-D-glucosaminidase increased, and urine volume and urinary excretions of furosemide and sodium decreased in the HgCl{sub 2}-treated rats. There were significant correlations between the urinary furosemide and its diuretic effects. Regression lines after HgCl{sub 2} were significantly different from those before treatment. The values of absorption as well as elimination rate constant were smaller, while the time to maximum concentration and the elimination half-life were longer in the HgCl{sub 2}-treated rats compared to vehicle-treated animals. These results suggest that the urinary excretion of furosemide and the responsiveness of renal tubular cells to this agent are impaired in rats with HgCl{sub 2}-induced acute renal damage.

• OSTI ID: 6952265
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 51:19; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
BODY
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DIURETICS
DRUGS
EXCRETION
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
MAMMALS
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
METABOLISM
ORAL ADMINISTRATION
ORGANS
PATHOLOGICAL CHANGES
RATS
RODENTS
TOXICITY
TUBULES
VERTEBRATES