Cellular reactivation of ultraviolet-irradiated human adenovirus 2 in normal and xeroderma pigmentosum fibroblasts
Journal Article
·
· Photochem. Photobiol., v. 19, no. 1, pp. 9-13
A plaque assay for adenovirus 2 on normal human fibroblasts was developed and used to measure the survival of ultravioletirradiated virus on six human fibroblast cell lines. When four xeroderma pigmentosum cell lines were used as viral hosts, an average of one lethal event per virus in the vinal population was made with 10, 15, 62, and 78 Jm/sup -2/ respectively, while using two normal cell lines as hosts, 197 and 205 Jm/sup -2/ were required to inflict the same damage. These differences are attributed to the known repair deficiency of xeroderma pigmentosum cells, and are discussed in the light of previous data obtained using other animal viruses. (auth)
- Research Organization:
- National Cancer Inst., Bethesda, MD
- NSA Number:
- NSA-29-024435
- OSTI ID:
- 4336334
- Journal Information:
- Photochem. Photobiol., v. 19, no. 1, pp. 9-13, Journal Name: Photochem. Photobiol., v. 19, no. 1, pp. 9-13; ISSN PHCBA
- Country of Publication:
- United Kingdom
- Language:
- English
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