Reduced superoxide dismutase activity in xeroderma pigmentosum fibroblasts
Journal Article
·
· Journal of Investigative Dermatology; (USA)
- Kyoto Univ. (Japan)
This study was performed in order to assess the possible protective effect of superoxide dismutase (SOD) on ultraviolet (UV) damage in xeroderma pigmentosum (XP) fibroblasts. SOD activity in fibroblasts originating from seven xeroderma pigmentosum (XP) patients was significantly lower than that in normal cells (p less than 0.005). Average SOD activity in XP cells belonging to complementation group A was 3.68 +/- 0.54 (n = 7) and that in normal human cells was 5.79 +/- 1.59 (n = 6). Addition of SOD before and during UV irradiation (UVB and UVC) to the cells caused no change in the amount of unscheduled DNA synthesis and UV survival. A possible involvement of reduced SOD in XP and a possible protective effect by SOD on UV damage is discussed.
- OSTI ID:
- 5407485
- Journal Information:
- Journal of Investigative Dermatology; (USA), Journal Name: Journal of Investigative Dermatology; (USA) Vol. 93:4; ISSN 0022-202X; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Induction of plasminogen activator by UV light in normal and xeroderma pigmentosum fibroblasts
Post-UV colony-forming ability of normal fibroblast strains and of the xeroderma pigmentosum group G strain
Somatic mosaicism for DNA repair capacity in fibroblasts derived from a group A xeroderma pigmentosum patient
Journal Article
·
Thu Oct 01 00:00:00 EDT 1981
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5922274
Post-UV colony-forming ability of normal fibroblast strains and of the xeroderma pigmentosum group G strain
Journal Article
·
Wed Dec 31 23:00:00 EST 1980
· J. Invest. Dermatol.; (United States)
·
OSTI ID:5762797
Somatic mosaicism for DNA repair capacity in fibroblasts derived from a group A xeroderma pigmentosum patient
Journal Article
·
Sun Oct 01 00:00:00 EDT 1989
· Journal of Investigative Dermatology; (USA)
·
OSTI ID:5467697
Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
ELECTROMAGNETIC RADIATION
ENZYMES
FIBROBLASTS
OXIDOREDUCTASES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
SUPEROXIDE DISMUTASE
SURVIVAL CURVES
ULTRAVIOLET RADIATION
XERODERMA PIGMENTOSUM
XP CELLS
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
ELECTROMAGNETIC RADIATION
ENZYMES
FIBROBLASTS
OXIDOREDUCTASES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
SUPEROXIDE DISMUTASE
SURVIVAL CURVES
ULTRAVIOLET RADIATION
XERODERMA PIGMENTOSUM
XP CELLS