BREPHOPLASTIC GRAFT OF THE SPLEEN ON THE KIDNEY CAPSULE OF THE NORMAL AND IRRADIATED MOUSE

Journal Article · Mon Feb 10 04:00:00 EST 1958 · Compt. rend.

OSTI ID:4332778

May, R -M; Thillard, M -J

A method was devised to determine the beneficial effects of spleen tissue against irradiation in nnice. Two mice, of the same line, were irradiated under 70 kv and 3 mamp for times varying from 15 nnin for 950 r to 16 min for 1000 r. Immediately after irradiation, one of the two mdce received spleen from a new-horn mouse grafted under the kidney capsule. The study shows that for radiation doses of 900 and 948 r the spleen tissue offers little protection, the percentage of survival being 65% for the controls and 68% for the grafted nnice. For radiation doses of 1000 r the percentage of deaths in the first week was 43.5% for the controls and 34% for the grafted mice. The percentage of survival after the fourth week was 52% for the grafted mice and 37.5% for the controls. In mice having a splenectomy before the brephoplastic graft, the spleen tissue does not seem to have any beneficial effect (J.S.R.)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-12-005822
• OSTI ID: 4332778
• Journal Information: Compt. rend., Journal Name: Compt. rend. Vol. Vol: 246
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

BIOLOGY AND MEDICINE
CONTROL
IRRADIATION
KIDNEYS
MICE
RADIATION DOSES
RADIATION PROTECTION
SPLEEN
SURGERY
SURVIVAL TIME
TRANSPLANTS