CONTRIBUTION TO THE STUDY OF THE HEMATOPOIETIC REGENERATION AFTER IRRADIATION BY X RAYS. I. REGENERATION OF SPLEEN GRAFTS IRRADIATED IN VIVO AND IN VITRO

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Annales d'Anatomie Pathologique (France)

OSTI ID:4205833

Booz, G

>As an introduction to a study of hematopoietic regeneration, the effects of x radiation on hematopoietic tissues, hematopoiesis and radiation resistance, and the factors affecting hematopoietic regeneration are discussed, and the results of previous studies are reviewed. The hematopoietic regeneration of splenic tissue of normal mice grafted to a young homozygote animal is first studied. After demonstrating the possibility of such a regeneration, the regenerating capacities of spleen grafts from animals irradiated in toto at increasing doses of x radiation are then investigated. The results showed that only after an irradiation of 10,000 r is a delay in the process of regeneration noticed. The spleens were irradiated in vitro, and the regeneration capacity when grafted to normal mice was determinnd. An exposure of 10,000 r was necessary to obtain a definite effect on the regeneration. (J.S.R.)

• Research Organization: Universite, Liege
• NSA Number: NSA-14-006137
• OSTI ID: 4205833
• Journal Information: Annales d'Anatomie Pathologique (France), Journal Name: Annales d'Anatomie Pathologique (France) Vol. Vol: 4; ISSN ANAPA
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

BIOLOGY AND MEDICINE
BLOOD FORMATION
BODY
MICE
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
REGENERATION
SPLEEN
TRANSPLANTS
X RADIATION