Intravascular survival of neutrophils labeled in vivo

Journal Article · Fri Mar 01 04:00:00 EDT 1974 · Blood, v. 43, no. 3, pp. 371-377

OSTI ID:4331159

Vincent, P C; Chanana, A D; Cronkite, E P; Joel, D D

The survival of blood neutrophils labeled in vivo with tritiated thymidine was studied in the calf. Disappearance of labeled neutrophils from the blood of calves was followed after a period of cross circulation with their chimeric, immunologically tolerant twins, which had been given tritiated thymidine 6.5 days previously. Under these conditions, neutrophils were shown to leave the blood in a random exponential fashion, with half-disappearance times of between 6.4 and 7.5 hr. Hydrocortisone given to one calf 48 hr after cross circulation caused a neutrophilic leukocytosis, during which substantial numbers of labeled neutrophils reappeared in the blood. (auth)

• Research Organization: Brookhaven National Lab., Upton, NY
• NSA Number: NSA-29-024559
• OSTI ID: 4331159
• Journal Information: Blood, v. 43, no. 3, pp. 371-377, Journal Name: Blood, v. 43, no. 3, pp. 371-377; ISSN BLOOA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*NEUTROPHILS-- SURVIVAL TIME
BLOOD CIRCULATION
CALVES
CHIMERAS
IMMUNITY
IN VIVO
LABELLED COMPOUNDS
N48720 --Life Sciences--Nuclide Kinetics & Toxicology--Animals
N48830* --Life Sciences--New Tracer Techniques--Other
THYMIDINE
TRITIUM
TRITIUM COMPOUNDS
UPTAKE