THE EFFECT OF IONIZING RADIATION ON THE SYNTHESIS OF PORPHOBILINOGEN AND OF PORPHYRIN (in Italian)
Journal Article
·
· Minerva nucleare
OSTI ID:4325368
The synthesis of porphyrins and porphobilinogen (PBG) was studied in the liver and kidney and in the erythrocytes of rats following x irradiation. Followlng irradiation there is a slight but constant increase of the copro- and protoporphyrin in the liver, kidney, and erythrocytes. Particularly in the red blood cells the increase is 6 times normal after 24 hours and persists until the 7th day, when it drops sharply to 0. The synthesis of protoporphyrins increases after irradiation, the increase being almost 20 times normal in the erythrocgtes after 24 hours and persisting until the 3rd or 4th day, though decreasing progressively. On the other hand the synthesis of coproporphyrins decreases in all the organs investigated and is practically inhibited on the 3rd day. The synthesis of porphobilinogen, i.e., the ala-dehydrase content, increases during the first 3 days in the liver and kidney and is practically unvaried in the erythrocytes. It seems probable that irradation alters the enzyme systems concerned with the synthesis of the porphyrin compounds. (auth)
- Research Organization:
- Istituto di Clinica Medica dell'Universita, Turin
- NSA Number:
- NSA-12-010310
- OSTI ID:
- 4325368
- Journal Information:
- Minerva nucleare, Journal Name: Minerva nucleare Vol. Vol: 2
- Country of Publication:
- Country unknown/Code not available
- Language:
- Italian
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