/sup 99m/Tc-pyrophosphate for bone imaging
Of the various /sup 99m/Tc-phosphates suggested for bone imaging, /sup 99m/Tc-pyrophosphate appears to have the desirable characteristics of commercial availability of sodium pyrophosphate and analytical controls available to assure the quality of the final product. Systematic variations of the parameters of the /sup 99m/Tctin-pyrophosphate preparations were evaluated by gamma camera images in swine. These studies indicate that the best distribution is obtained by adding 1.75 ml of 0.1 M sodium pyrophosphate at pH 10 to 0.25 ml of l mg/ml stannous chloride followed by 1.50 ml /sup 99m/TcO/sub 4/-. In vivo organ distribution indicates the importance of normalizing doses on a per weight basis for comparative animal studies. Data reported for /sup 99m/Tc-phosphates without consideration of the dose on a weight basis can be misleading. If the optimal dose of pyrophosphate is used, /sup 99m/Tc-pyrophosphate results in high-quality bone images in animals and humans and can be easily prepared and assayed. (auth)
- Research Organization:
- George Washington Univ., Washington, DC
- NSA Number:
- NSA-29-029934
- OSTI ID:
- 4324166
- Journal Information:
- J. Nucl. Med., v. 15, no. 4, pp. 279-283, Journal Name: J. Nucl. Med., v. 15, no. 4, pp. 279-283; ISSN JNMEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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