Decomposition of Tc-99m pyrophosphate by peroxides in pertechnetate used in preparation

Journal Article · Wed Jul 01 04:00:00 EDT 1981 · J. Nucl. Med.; (United States)

OSTI ID:6461123

Der, M; Ballinger, J R; Bowen, B M

We describe an investigation of the stability of Tc-99m pyrophosphate (Tc-99m PPi). We have shown that addition of exogenous hydrogen peroxide to Tc-99m PPi can initiate the oxidation of the complex, giving rise to 95% unbound pertechnetate. The presence of endogenous hydrogen peroxide in the sodium pertechnetate used in the preparation of Tc-99m PPi has been thought to influence its stability. We have prepared it using pertechnetate solutions of different specific activities. After preparation, an alumina column was used to detect free /sup 99m/TcO/sub 4//sup -/. The Tc-99m PPi and Na/sup 99m/TcO/sub 4/ solutions were then assayed by iodometric titration for hydrogen peroxide, which was detected in the pertechnetate solutions. The higher the specific activity of the solution used for the tracer preparation, the faster was the production of free pertechnetate.

• Research Organization: Chedoke-McMaster Hospital, Hamilton, Ontario
• OSTI ID: 6461123
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
CHEMICAL REACTION KINETICS
CHEMICAL REACTIONS
DECOMPOSITION
DRUGS
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
OXIDATION
OXYGEN COMPOUNDS
PEROXIDES
PERTECHNETATES
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIOISOTOPES
RADIOPHARMACEUTICALS
REACTION KINETICS
STABILITY
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES