Chromosome aberrations induced by ultraviolet radiation

Journal Article · Sat Jan 01 04:00:00 EST 1972 · Photophysiol. Curr. Top., v. 7, pp. 189-205

OSTI ID:4323720

Wolff, S

In recent years, studies with uv on the induction of chromosome aberrations have centered on work with mammalian cells in tissue culture. Such cultured cells have many characteristics that make them more suitable than plants for ultraviolet studies. Dosimetric problems are minimized and difficulties arising from complex biological responses can be analyzed. The problems that still exist, even with cultured cells, are so formidable, however, that we have not as yet been able to realize the full potential uv holds for understanding the nature of those radiation-induced mutagenic events manifested as chromosome aberrations. Nevertheless, the use of uv still holds its promise for such understanding, and as the responses of cultured cells become better understood, we can anticipate that uv will become increasingly important in studies of radiation-induced chromosome breakage. (auth)

• Research Organization: Univ. of California, San Francisco
• NSA Number: NSA-29-018568
• OSTI ID: 4323720
• Report Number(s): UCSF--10-P-2-176
• Journal Information: Photophysiol. Curr. Top., v. 7, pp. 189-205, Journal Name: Photophysiol. Curr. Top., v. 7, pp. 189-205; ISSN PHCTB
• Country of Publication: United States
• Language: English

Related Subjects

*ANIMAL CELLS-- CHROMOSOMAL ABERRATIONS
*CHROMOSOMAL ABERRATIONS-- RADIOINDUCTION
BIOLOGICAL RADIATION EFFECTS
DOSIMETRY
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
PHOTON BEAMS
REVIEWS
TISSUE CULTURES
ULTRAVIOLET RADIATION RADIOINDUCTION