INDIRECT EFFECTS DURING X-RADIATION OF MALIGNANT TUMORS
The respiratory and glycolytic metabolism of several nonmalignant and tumor tissues have been compared in normal peripheral dog lymph and in peripheral dog lymph withdrawn from corresponding normal tissues of the same animal 3 hours after a dose of 450 r x radiation. With bicarbonate in equilibrium CO/sub 2/ buffering, tumor tissues were found to show lower values of respiration and glycolysis in the peripheral lymph from x-irradiated tissues than in normal peripheral lymph. Conversely, the respiration of a nonmalignant tissue was found to be enhanced in the lymph from x-irradiated tissues. When the bicarbonate in equilibrium C0/sub 2/ buffer system of the lymph was artificially replaced by phosphate, the opposite effect was observed, i.e., the respiration of tumor tissues was enhanced in the lymph from x-irradiated tissues, while the respiration of nonmalignant tissues was depressed. The infiuence of the buffer system and the effect of dissolved anesthetic in the lymph have been discussed. The results provide evidence in support of an indirect action during x irradiation of malignant tumors. It is suggested that absorption of radiation by the normal cells of the tumor bed and stroma of a neoplasm may cause these cells to liberate biologically active substances iato the interstitial fiuid. Diffusion of this interstitial fiuid throughout the tumor mass could then provide an environment in which the respiratory metabolism of malignant cells appears to be depressed, while that of nonmalignant cells appears to be enhanced. (auth)
- Research Organization:
- Liesbeek Cancer Research Clinic, Rosebank, Cape Town
- NSA Number:
- NSA-13-002655
- OSTI ID:
- 4313615
- Journal Information:
- Cancer Research, Journal Name: Cancer Research Vol. Vol: 18
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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