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RADIOPROTECTIVE PROPERTIES OF CYSTAMINE, CYSTEAMINE AND CYSTEINE WHEN TESTED WITH CHICK FIBROBLASTS IN VITRO

Journal Article · · Nature
DOI:https://doi.org/10.1038/181344b0· OSTI ID:4312878
A series of experiments on the effects of cystamine, cysteamine, and cysteine when added to cultures of chick fibroblasts shortly before x irradiation is reponted. The results showed that for 200 r irradiated cultures the mitotic inhibition was not influenced by the addition of either cystamine or cysteine. Several concentrations of cystamine, cysteamine, and cysteine were tested after addition of 0.89 mM cystamine-2 hydrochloride before irradiation with 1,500 or 2,000 r helps the cultures through the critical phase which seems to occur after 4 to 6 passages. No similar protective effect could be found for cysteamine or cysteine. (J.S.R.)
Research Organization:
Norwegian Radium Hospital, Oslo
Sponsoring Organization:
USDOE
NSA Number:
NSA-12-005184
OSTI ID:
4312878
Journal Information:
Nature, Journal Name: Nature Vol. Vol: 181
Country of Publication:
Country unknown/Code not available
Language:
English