INDIRECT EFFECTS OF X-IRRADIATION ON THE THYROID OF THE CHICK EMBRYO

Technical Report · Thu Jun 12 04:00:00 EDT 1958

OSTI ID:4311446

Brayer, F T; Glasser, S R; Casarett, G W; Howland, J W

The I-131 uptake by the thyroid of the 12 to 17 day old chick embryo is significantly elevated 24 hours after exposure to 600r of x-irradiation. A comparable increase in the thyroidal uptake of I-131 can be elicited by injecting 0.1 ml. of pooled sera from x-irradiated chick embryos into untreated embryos. Injected purified, bovine thyrotrophic hormone also significantly increases thyroidal uptake of I-131 in the chick embryo. Histologic sections from x- irradiated embryos, embryos injected with pooled sera obtnined from x-irradiated embryos, and embryos injected with purified bovine or crude avian thyrotrophic hormone all show a gualitatively similar regional stimulation of thyroid tissue. It is concluded from the data that exposure of the chick embryo to x-irradiation releases a substance into the systemic circulation which mediates the demonstrated signiflcant increase in 1-131 uptake by the thyroid and that this substance is thyrotrophic hormone. (auth)

• Research Organization: Rochester, N.Y. Univ. Atomic Energy Project
• NSA Number: NSA-12-013662
• OSTI ID: 4311446
• Report Number(s): UR-526
• Country of Publication: United States
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BIRDS
BLOOD CIRCULATION
BLOOD SERUM
CATTLE
COPPER
CYTOLOGY
EMBRYOS
EXCITATION
HORMONES
HYDROCHLORIC ACID
IMPURITIES
INDIUM
INDIUM ALLOYS
IODINE 131
METABOLISM
ORGANIC COMPOUNDS
PHOTOMETRY
QUANTITATIVE ANALYSIS
RADIATION DOSES
RADIATION EFFECTS
SOLUTIONS
SPARK CHAMBERS
SPECTROSCOPY
THYROID
TSH
URANIUM ALLOYS
VARIATIONS
X RADIATION