THYROID HORMONE BIOSYNTHESIS IN IRRADIATED CHICK EMBRYOS
X irradiation of 12-day chick embryos increased the 24-hour thyroid uptake of I/sup 131/ of surviving embryos. The chromatographic pattern of the thyroids was markedly altered by a significant increase in the MIT-DIT fraction and of T/sub 3/. T/sub 3/ (0.5 mu g), either alone or in combination with 600 r x rays, had no effect on growth, survival, or thyroid I/sup 131/ uptake. However, T/sub 3/ did alter the distribution of iodinated compounds in the embryonic thyroid. The influence of x irradiation on the thyroid chromatographic pattern of T/sub 3/-treated embryos was qualitatively similar to that seen in untreated irradiated embryos. However, the increase in MIT-DIT was derived at the expense of T/sub 3/ and T/sub 4/ rather than from the additional concentration of li3l. The probable locus of action of radiation on thyroid hormone biosynthesis and the possible significance of the changes on the growth and development of surviving embryos are discussed. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- NSA Number:
- NSA-16-031473
- OSTI ID:
- 4778820
- Report Number(s):
- UR-616
- Country of Publication:
- United States
- Language:
- English
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