Mg$sup 28$ TRACER STUDIES OF MAGNESIUM METABOLISM IN ANIMALS AND HUMAN BEINGS
Technical Report
·
OSTI ID:4308409
methods for the separation of magnesium from calcium in biologic material. The molybdivanante colorimetric cretion and tissue distribution of Mg/ sup 28/ was studies in itially in rabbits. The relationship between change in magnesium content and body weight during starvation was also studied in rabbits. The oral administration to human beings of a tracer dose of this isotope as MgSO/ sub 4/ or MgCl/sub 2/ resulted in the urinary excretion of less than 6% of the radioactivity within 24 hours; most of the Mg/sup 28/ was recovered from the stool. Following the intravenous infusion of 50 microcuries of Mg/sup 28/ in 5 to 10 milliequivalents of Mg, radioactivity concentration in the plasma decreased rapidly during the initial three hours and slowly exponentially between 14 to 27 hours. The specific activities of plasma and urine diminished gradually during the latter phase. Urinary excretion of 20 to 25% of the radioactivity occurred within the first 24 hours and was minimal thereafter. Facal excretion was less than 2% of the infused dose. The exchangeable magnesium values calculated from thc specific activities of plasma and urine were considerably lower then the estimated body magnesium constant. Surface monitoring over the body of human subjects given the intravenous infusions of Mg/sup 28/ revealed maximal conventration of radioactivity over the liver within the first three house. There was minimal concentration of radioactivity over bone and muscle masses. (auth)
- Research Organization:
- Colorado. Univ., Denver. School of Medicine
- NSA Number:
- NSA-12-014595
- OSTI ID:
- 4308409
- Report Number(s):
- A/CONF.15/P/1040
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
BIOLOGY AND MEDICINE
BLOOD CIRCULATION-- BLOOD PLASMA-- BODY-- BONES-- DISTRIBUTION-- INTESTINE-- LIVER-- MAGNESIUM-- MAGNESIUM 28-- MATHEMATICS-- METABOLISM-- MONITORING-- MUSCLES-- QUANTITY RATIO-- RADIATION DOSES-- RADIOACTIVITY-- SURFACES-- URINE-- VARIATIONS
BODY-- CALCIUM-- COLOR-- COLORIMETRY-- CONFERENCE-- DISTRIBUTION-- FOOD-- INTESTINE-- MAGNESIUM CHLORIDES-- MAGNESIUM SULFATES-- MAGNESIUM 28-- MEASURED VALUES-- METABOLISM-- QUALITATIVE ANALYSIS-- QUANTITY RATIO-- RABBITS-- RADIATION DOSES-- TISSUES-- TRACER TECHNIQUES-- URINE-- VARIATIONS-- WEIGHT
BLOOD CIRCULATION-- BLOOD PLASMA-- BODY-- BONES-- DISTRIBUTION-- INTESTINE-- LIVER-- MAGNESIUM-- MAGNESIUM 28-- MATHEMATICS-- METABOLISM-- MONITORING-- MUSCLES-- QUANTITY RATIO-- RADIATION DOSES-- RADIOACTIVITY-- SURFACES-- URINE-- VARIATIONS
BODY-- CALCIUM-- COLOR-- COLORIMETRY-- CONFERENCE-- DISTRIBUTION-- FOOD-- INTESTINE-- MAGNESIUM CHLORIDES-- MAGNESIUM SULFATES-- MAGNESIUM 28-- MEASURED VALUES-- METABOLISM-- QUALITATIVE ANALYSIS-- QUANTITY RATIO-- RABBITS-- RADIATION DOSES-- TISSUES-- TRACER TECHNIQUES-- URINE-- VARIATIONS-- WEIGHT