ANTIBODY RESPONSE OF MICE TREATED WITH 2-MERCAPTOETHYLGUANIDINE HYDROBROMIDE AND LETHAL DOSES OF X-RADIATION, AND ITS SIGNIFICANCE TO THE RELATION OF ANTIGEN TO HOST
Journal Article
·
· Journal of Immunology (U.S.)
OSTI ID:4304219
No importamt difference between sheep and rat agglutinin production was observed in normal and MEG (2-mercaptoethylguamidine hydrobromide) treated mice. The sheep agglutinin response was higher than rat agglutinin response in the 475- r, 700-r, 950 r-IBM (isologous bone marrow) treated, and MEG-950 r mice. Such difference was based on the induction period of agglutinin response, peak agglutinin titer, snd on the mean total agglutinin response. The rate of recovery of the immune mechanism of MEG-950 r mice was almost comparable to that of the 475-r mice. Thc rate of recovery of the immune mechanism of MEG-950 r mice was not significantly different from that of the 950 rIBM mice. The results permit the deductions that MEG protects predominantly nonantibody producing cells; that either multiple types of antibody producing cells exist or some antibody producing cell has the ability to recognize the difference between homologous, closely related heterologous, amd distantly related heterologous antigens; and that the degree of destruction of antibody forming cells by x- irradiation is in the order mentioned. (auth)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- NSA Number:
- NSA-12-011244
- OSTI ID:
- 4304219
- Journal Information:
- Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 79; ISSN JOIMA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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