SPECIFIC HEMAGGLUTININS IN X-IRRADIATED, BONE MARROW TREATED MICE FOLLOWING DIFFERENTIAL IMMUNIZATION OF HOST AND DONOR
Technical Report
·
OSTI ID:4293027
An effort was made to evaluate the immunological capabilities of the x- irradiated (870 r), bone marrowtreated mouse, with respect to the relative contribution of the host's own tissues and of the cellular elements derived from the injected bone marrow. In one experiment rats and mice to be used as bone marrow donors were sensitized to one of two antigens (sheep or human erythrocytes). The mice to be used as irradiated recipients were sensitized to the other antigen. In another experiment, mice were used as both bone-marrow donor and host, and either the donor or host, or neither one, was sensitized to either sheep or human erythrocytes. Groups from each experiment were given booster injections of antigen at various times after irradiation. Anti-sheep- ervthrocyte and anti-human-ervthrocyte agglutinin titers were determined on each group at periodic intervals after irradiation. All marrow-treated irradiated mice cortinued to prcduce antibodies if sensitized prior to irradiation. The isologous bone marrow-treated pre-sensitized mice reacted to a booster with a secondary response, while the heterologous bone marrow-treated mice did not. The isologous bone marrow-treated mice were capable of a primary response, but the heterologous bone marrow-treated mice were not. The results may be interpreted as evidence that the primary response is radiosensitive and antibedy production is relatively insensitive. The secondary immune response is relatively radioresistant. Treatment with isologous bone marrow leads to recovery of essentially normal immune response in the isologous chimaeras. In the heterologous chimaera, the immune response is, at all times, at a very low level. (anth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-13-002637
- OSTI ID:
- 4293027
- Report Number(s):
- USNRDL-TR-271
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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