INFLUENCE OF THE NUCLEOLUS ON MITOSIS AS REVEALED BY ULTRAVIOLET MICROBEAM IRRADIATION
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.
Exposure of one nucleolus in a grasshopper neuroblast to a microspot of high-intensity ultraviolet radiation for 3 seconds permanently stops mitosis of cells irradiated in stages from late telophase to the middle of middle prophase. During the latter half of middle prophase, the cell becomes mitotically less sensitive to nucleolar irradiation and by iate prophase is completely insensitive to it. Microspot irradiation of a nonnucleolar region of the nucleus causes mitotic delay but does not usually prevent cell division. These observations support the hypothesis that the nucleolus has an intimate functional relation to the mitotic process. (auth)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-12-012118
- OSTI ID:
- 4301752
- Journal Information:
- Proc. Natl. Acad. Sci. U.S., Journal Name: Proc. Natl. Acad. Sci. U.S. Vol. Vol: 44
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Mitotic effects of monochromatic ultraviolet radiation at 225, 265, and 280 nm on eleven stages of the cell cycle of the grasshopper neuroblast in culture. II. Changes in progression rate and cell sequence between the stage irradiated and nuclear membrane breakdown
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Mitotic effects of monochromatic ultraviolet radiation at 225, 265, and 280 nm on eleven stages of the cell cycle of the grasshopper neuroblast in culture. I. Overall retardation from the stage irradiated to nuclear membrane breakdown
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· Radiat. Res.; (United States)
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OSTI ID:7330199