THE BEHAVIOR OF THE ALKALINE PHOSPHATASE ACTIVITY OF THE LIVER OF THE RAT AFTER WHOLE-BODY X IRRADIATION WITH A LETHAL DOSE

Journal Article · Wed Jan 01 04:00:00 EST 1958 · Radiobiologica Latina

OSTI ID:4298566

Francesco, F; Adalberto, M

DOSE. Finocchio Francesco and Malaspina Adalberto (Univ. of Messina, ltaly and Istituto Radiologico dell' Ospedale Maggiore, Novara, ltaly). Radlobiologica Latina 1, 40-53(19581 jan.-Mar. (In Italian) The modification of the enzyme activity of the rat liver during the first 168 hours after a slngle irradiatlon of 800 r over the whole body was studied. Gomori's method for alkaline phosphatase with different periods of incubation was used and the following results were obtalned: The alkallne phosphatase activity augments ln the endothelial cells of intralobular caplllaries during the flrst days after lrradlation, whlle lt dlsappears for a few days, returnlng on the seventh day to its normal activity. The alkaline phosphatase activity diminishes in the nucleus of liver cells and in bile capillaries, completely disappearing about the fourth day after irradiatlon. lt is stlll absent on the seventh day after irradiation. The alkaline phosphatase activity of the connective tissue of interlobular spaces and of the reticular fibers of the outer part of the liver lobules is markedly reduced and persists only in the adventitia of small bile ducts. (auth)

• Research Organization: Univ. of MEssina, italy; IStituto Radiologico dell'Ospedale Maggiore, Novara, Italy
• NSA Number: NSA-13-001932
• OSTI ID: 4298566
• Journal Information: Radiobiologica Latina, Journal Name: Radiobiologica Latina Vol. Vol: 1
• Country of Publication: Country unknown/Code not available
• Language: Italian

Related Subjects

ANIMAL CELLS
BILE DUCTS
BIOLOGY AND MEDICINE
BLOOD VESSELS
BODY
CAPILLARIES
CONNECTIVE TISSUE
ENZYMES
IRRADIATION
LETHAL DOSE
LIVER
METABOLISM
PHOSPHATASES
QUANTITY RATIO
RATS
TISSUES