SHORT AND LONG-TERM OBSERVATIONS CONCERNING THE EFFECT OF HOMOLOGOUS AND HETEROLOGOUS CELL-FREE SPLEEN EXTRACTS ON RADIATION MORTALITY IN MICE AND GUINEA PIGS
Journal Article
·
· Atompraxis (West Germany) Incorporated in Kerntechnik
OSTI ID:4277437
The present studies implement and extend previous reports of investigations concerned with the radiation protection of cell-free saline extracts from spleens. Previous preliminary data are implemented by showing that cell-free saline extracts from mouse spleens protect guinea pigs against radiation death at 3 radiation dose levels. The reduction of radiation mortality is reflected in the weight change curve of the spleenextract treated animals, which indicates suppression and reduction of weight loss respectively observed in pertinent saline controls. Protective spleen extracts can also be obtained from the spleens of guinea pigs. The post-irradiation treatment of mice and guinea pigs with mouse spleen extract does not only reduce mortality in both species in the immediate post-irradiation period (up to the 20th post-irradiation day), but that the number of survivors at the 20th post-irradiation day remains unchanged for over 3 months. This survival is accompanied by consistent weight gain in both species, indicative of the absence of late immunobiological response (so- called rejection-reaction) to cellular implants frequently encountered when preparations containing viable cells are used for the modification of the lethal effect of irradiation. Besides this advantage over cell-containing extracts, these cell-free preparations can be stored up to 3 months without a loss in protective effect. (auth)
- Research Organization:
- National Naval Medical Center, Bethesda, Md.
- NSA Number:
- NSA-13-007384
- OSTI ID:
- 4277437
- Journal Information:
- Atompraxis (West Germany) Incorporated in Kerntechnik, Journal Name: Atompraxis (West Germany) Incorporated in Kerntechnik Vol. Vol: 4; ISSN ATPXA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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