Effects of Cell-Free Spleen Extract Treatment on the Hematopoietic Tissues of Irradiated Guinea-Pigs

Journal Article · Thu Jul 01 04:00:00 EDT 2004 · Acta Haematologica

DOI:https://doi.org/10.1159/000206667· OSTI ID:4737818

Ellinger, Friedrigh; Strike, Thomas A.

Guinea pigs were given whole-body Co⁶⁰ irradiation (650 r) and injected daily thereafter with cell-free extracts of homologous and heterologous spleen. Spleen of irradiated control guinea pigs showed a progressive reduction of alkaline phosphatase staining commencing after the 3rd postirradiation day and reaching a maximum on or about the 9th day. Treatment of the animals with spleen extracts modified the radioinduced changes in alkaline phosphatase staining, so that an almost normal appearance was noted over the entire 14-day observation period. Most of the alkaiine phosphatase-staining spleen elements were mature neutrophils. It was concluded that spleen extract treatment affects apparently various celluiar elements of spleen in a different way. The results support the hypothesis that protection of phosphorylization processes against effects of irradiation represent one of the mechanisms by which the radiation protective effect of spleen extracts is effected.

• Research Organization: Naval Medical Research Inst., Bethesda, Md.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-010370
• OSTI ID: 4737818
• Journal Information: Acta Haematologica, Journal Name: Acta Haematologica Journal Issue: 5 Vol. 26; ISSN 0001-5792
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
BIOCHEMISTRY
BODY
ENZYMES
GAMMA RADIATION
GUINEA PIGS
LEUCOCYTES
NEUTROPHILS
PHOSPHATASES
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RECOVERY
SPLEEN