PHARMACOLOGICAL STUDIES ON IIRRADIATED ANIMALS. X. EFFECTS ON HEMATOPOIETIC TISSUES OF IRRADIATED GUINE PIGS. Report No. 5

Technical Report · Fri Jan 01 04:00:00 EST 1960

OSTI ID:4035126

Ellinger, F; Strike, T

Qualitative and quantitative histological snd histochemical evidence is presented which indicates that cell-free saline spleen extracts modify radiation induced changes in the spleen and bone rnarrow of guinea pigs following exposure to an LD/sub 75///sub 20/ of Cow gamma radiation. Post-irradiation treatment with homologous or heterologous (mouse) spleen extract accelerates the matural recovery process of the spleen and bone rnarrow of guinea pigs, while the initial effect remains unchanged. Histological findings gave the impression that the accelerated recovery process is caused by a stimulatcry effect of the spleen extract on stern cell. Histochemical studies indicate that spleen extracts also modlfy the radiation effect on the alkaline phosphatase staining cells of the spleen. Since homologous or heterologous extracts produce similar results, a common mechanian of recovery was postulated. Study of the temporal sequence of changes indicates that recovery processes in spleen precede those in bone marrow, thus indicating a "hierarchy" of events. The significance of the findings for biology and clinical medicine is discussed. (auth)

• Research Organization: Naval Medical Research Inst., Bethesda, Md.
• NSA Number: NSA-15-023286
• OSTI ID: 4035126
• Report Number(s): NP-10297; DASA-516 Pt.10
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE