THE EFFECT OF IONIZING RADIATION ON THE DEVELOPMENT OF IMMUNITY TO TETANUS AND TYPHOID
The general x-ray irradiation of mice (550 r) 2 days before immunization caused a marked fall in antitoxic (anti-tetanus) and in antibacterial (anti- typhoid) immunity. The immunity developing after the mice had been vaccinated (with 3 injections of tetravalent vaccine and 2 injections of crude toxoid) during a period when they exhibited marked symptoms of radiation sickness was only greater than the natural resistance of nonimmunized healthy mice to injections of tetanus toxin and to infection with typhoid bacilli. When mice were immunized 2 days after general irradiation with purified adsorbed toxoid the immunogenic properties of which greatly exceed those of ordinary crude toxoid, they exhibited a higher degree of antitoxic immunity than was obtained with ordinary toxoid; however, the difference in the immunological efficacy of these two preparations was less marked in the irradiated animals than in animals which had not been irradiated. (auth)
- Research Organization:
- Military Medical Academy
- NSA Number:
- NSA-13-007408
- OSTI ID:
- 4277280
- Journal Information:
- J. Microbiol. Epidemiol. Immunobiol. (USSR) (English Translation), Journal Name: J. Microbiol. Epidemiol. Immunobiol. (USSR) (English Translation) Vol. Vol: 28
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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