Synthesis of IgM and IgG antibodies in mice irradiated with x rays and immunized with tetanus toxoid (in Polish)
White mice were immunized with adsorbed tetanus toxoid 1 to 2 hrs following irradiation with a dose of 300 R. The antibody response was tested in whole sera 7, 14, 28, and 42 days after immunization; it was found to be delayed and repressed compared with controls. In tests for antibody activity of different classes of immunoglobulins, isolated on Sephadex G-200, the IgM- producing mechanisms were found to be highly radiosensitive; peak of the response was greatly delayed (28 days); and peak titers were threefold lower than in controls. IgG antibody production also was delayed and in the initial period it was repressed. Six weeks after irradiation, IgG antibody levels were equal in the irradiated and control mice. The present results concerning radiosensitivity of IgM-producing mechanisms are discordant with data of other authors, who immunized animals with other antigens or investigated the metabolism of immunoglobulins in irradiated but nonimmunized animals. (auth)
- Research Organization:
- Panstwowy Zaklad Higieny, Warsaw
- NSA Number:
- NSA-29-005334
- OSTI ID:
- 4389520
- Journal Information:
- Med. Dosw. Mikrobiol., v. 24, pp. 255-265, Journal Name: Med. Dosw. Mikrobiol., v. 24, pp. 255-265; ISSN MDMIA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Polish
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