QUARTERLY PROGRESS REPORT NO. 30

Technical Report · Thu Jan 15 04:00:00 EST 1959

OSTI ID:4275427

Preliminary screening studies were conducted on forty fermentation broths in an effort to determine whether such materials might offer sources of radioprotective substances. Both prophylactic and therapeutic effects against radiation injuries were observed with scveral of the broths, and it was concluded that additional studies with such materials are warranted. Thirty chemical compounds were tested for their protective effects against radiation injuries in mice. Data are tabulated. Ultraviolet spectrophotometric and analytical methods were devised to study the kinetics of the nucleophilic displacement reactions of cyclic imines with thiourea and its analogs. Preliminary rate measurements on the thiourea-ethylenimine reaction and the competitive solvolysis of the aziridinium ion point to the SN/sub 2/ mechanism In the ring opening reaction. Synthetic and spectral data are presented to provide evidence for the existence of the charge-separated form of tetramethyl thiourea. Additional synthetic work relating to the kinetic and product identiiication phases of the study and a radioprophylaxis program are reported. Results are summarized from studies on the effccts of x irradiation on the synthesis of citric acid by rat tissues in vitro, the radioprotective effects of certain enzyme inhibitors in animals, measurements of the radioprotective effect of various chemical agents by their ability to modify the radiation-induced changes in the activity of certain enzymes of the intestine, spleen, and thymus gland of rats and mice, and the effects of fractionated low-level doses of gamma and fast neutron irradiation on the life span and reaction time of mice. (For preceding period see NP-7018.) (C.H.)

• Research Organization: Chicago. Univ. Air Force Radiation Lab.
• NSA Number: NSA-13-009564
• OSTI ID: 4275427
• Report Number(s): NP-7301
• Country of Publication: United States
• Language: English

Related Subjects

AGE-- DOSE FRACTIONATION-- FAST NEUTRONS-- GAMMA RADIATION-- MICE-- RADIATION DOSES-- RADIATION EFFECTS-- SURVIVAL TIME
ANIMAL CELLS-- BIOCHEMISTRY-- CITRIC ACID-- RADIATION EFFECTS-- RATS-- TISSUES-- X RADIATION
ANIMALS-- BIOCHEMISTRY-- CHEMICALS-- ENZYMES-- INTESTINE-- MICE-- RADIATION PROTECTION-- RATS-- SPLEEN-- THYMUS
BIOLOGY AND MEDICINE
CHEMICALS-- MICE-- RADIATION INJURIES-- RADIATION PROTECTION-- TABLES-- TESTING
CHEMICALS-- RADIATION PROTECTION-- REACTION KINETICS
EFFICIENCY-- FERMENTATION-- MEDICINE-- RADIATION INJURIES-- RADIATION PROTECTION-- TESTING-- THERAPY
ORGANIC NITROGEN COMPOUNDS-- ORGANIC SULFUR COMPOUNDS-- PHOTOMETRY-- REACTION KINETIC