EFFECT OF X-IRRADIATION ON INCORPORATION OF UREIDOSUCCINIC ACID-C$sup 14$ INTO NUCLEIC ACID PYRIMIDINES

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Radiation Research

DOI:https://doi.org/10.2307/3570728· OSTI ID:4269665

Yen, C Y; Anderson, E P; Smith, P K

idosuccinic acid-C/sup 14/ into nucleic acid pyrimidines has been made on normal and x-irradiated mice. Total-body x irradiation of 400 r inhibited uptake of this compound into individual DNA pyrimidines, particularly in spleen, and produced increased incorporation into PNA pyrimidines in both liver and spleen. In a series studied at various times after irradiation, total activity in cold and hot TCA fractions of liver and spleen also tended to be above that of normal animals, particularly at 92 hours after irradiation; the effect was less marked at earlier periods, and at 68 hours after irradiation the activity in the hot TCA fraction was actually below the normal level. This may indicate that inhibition or stimulation of the incorporation of this compound by x irradiation is a function of the time period after irradiation. (auth)

• Research Organization: George Washington Univ., Washington, D.C.
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-016712
• OSTI ID: 4269665
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 11
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOCHEMISTRY
BIOLOGY AND MEDICINE
BODY
CARBON 14
DNA
LABELLED COMPOUNDS
LIVER
METABOLISM
MICE
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIOACTIVITY
SPLEEN
SUCCINIC ACID
TEMPERATURE
VARIATIONS
X RADIATION