THE EFFECT OF WHOLE-BODY X IRRADIATION ON THE BACTERICIDAL ACTIVITY OF PHAGOCYTIC CELLS. II. SURVIVAL OF PSEUDOMONAS AERUGINOSA WITHIN LIVERS AND SPLEENS OF MICE

Journal Article · Thu Jan 01 04:00:00 EST 1959 · J. Infectious Diseases

DOI:https://doi.org/10.1093/infdis/104.1.20· OSTI ID:4265284

Nelson, E L; Becker, J R

Mice irradiated five days previously with doses of 0, with Pseudomonas aeruginosa. Immediately thereafter, aa antibiotic was also injected intravenously to kill extracellular bacteria. Livers and spleens were removed from the infected mice 0, 4, and 24 hours later, ground, and the total numbers of viable bacteria determined by culture methods. The results indicate that the bacteria survived and multiplied within the spleens and livers of mice receiving 500 to 700 r X radiation but were destroyed in the organs of normal mice and mice receiving the lower doses of X irradiation (100 to 300 r). In mice previously immunized with killed Pseudomonas the bacteria did not survive within the livers and spleens even though the animals were subjected to 500 to 700 r. (auth)

• Research Organization: Univ. of Chicago
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-011575
• OSTI ID: 4265284
• Journal Information: J. Infectious Diseases, Journal Name: J. Infectious Diseases Vol. Vol: 104
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIBIOTICS
BACTERIA
BIOLOGY AND MEDICINE
IMMUNITY
INFECTIONS
IRRADIATION
LIVER
MICE
PHAGOCYTOSIS
PSEUDOMONAS
PSEUDOMONAS AERUGINOSA
RADIATION DOSES
SPLEEN
VACCINATION
VARIATIONS
X RADIATION