Bactericidal Activity of Fixed Phagocytes in Irradiated and Unirradiated Mice Treated with RNA.

Journal Article · Tue Oct 01 04:00:00 EDT 1963 · Experimental Biology and Medicine

DOI:https://doi.org/10.3181/00379727-114-28629· OSTI ID:4171640

Hammond, C. W.

CF1 female mice 9 to 10 weeks old were injected intravenously with RNA 30 min before or on the 4th day after exposure to a sublethal dose of x irradiation (550 r). Simultaneously an equal number of irradiated mice were injected intravenously with buffered saline to serve as controls. On the 5th day post-irradiation all mice were injected intravenously with Ps. aeruginosa followed 1 min later by intravenous polymyxin or colymycin. The next day all mice were killed and heart's blood cultured. Livers and spleens were removed, ground separately in tissue grinders and appropriate dilutions plated. The results of the bacterial counts indicated that the mean number of pseudomonads in livers and spleens of mice injected with RNA were slightly lower than the mean number in livers and spleens of controls but the difference was not significant. Similar results th RNA 4 days before challenge with Ps. aeruginosa.

• Research Organization: Univ. of Illinois, Chicago
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-000109
• OSTI ID: 4171640
• Journal Information: Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 1 Vol. 114; ISSN 1535-3702
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AGE
ANTIBIOTICS
BACTERIA
BLOOD
INFECTIONS
IRRADIATION
LIVER
MICE
POLYMYXIN
PSEUDOMONAS
QUANTITY RATIO
RADIATION DOSES
RADIATION PROTECTION
RIBONUCLEIC ACID
SALTS
SOLUTIONS
SPLEEN
X RADIATION