Isotopic Exchange Reaction Between Diiodofluorescein and Potassium Iodide; OBMEN IODA MEZHDU DIIODFLUORESTSEINOM I IODISTYM KALIEM

Technical Report · Sat Oct 31 04:00:00 EST 1959

OSTI ID:4264424

Ralkova, J

>The kinetics of the isotopic exchange of the iodine ion between diiodofluorescein (IFI) and KI was studied. Methanol was used as a solvent. Diiodofluorescein labelled with I/sup 131/ is required for medical purposes to localize brain tumors. One may suppose that two atoms of iodine in the molecule of diiodofluorescein are chemically equivalent, as demonstrated by the results obtained. The exchange rate was evaluated for different concentrations and different temperatures. The exchange probably follows the reaction of the second order, and the activation enengy of this exchange was found to be 9650 plus or minus 150 cal/mole. The carbon-iodine bond is strongly polarized, as shown by the relatively short half-time and small activation energy. This method can be used for preparing diiodofluorescein labelled with I/sup 131/. (auth)

• Research Organization: Czechoslovakia
• NSA Number: NSA-13-006407
• OSTI ID: 4264424
• Report Number(s): A/CONF.15/P/2111
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BINDING ENERGY
BRAIN
CHEMICAL REACTIONS
CHEMISTRY
CRYSTALS
DIPOLES
DRUGS
DYES
ENERGY LEVELS
EXCITATION
FLUORESCEIN
FLUORESCENCE
ISOTOPIC EXCHANGE
LATTICES
LIFETIME
MEDICINE
ORGANIC COMPOUNDS
ORGANIC IODINE COMPOUNDS
POTASSIUM IODIDES
PREPARATION
REACTION KINETICS
SOLUTIONS
SOLVENTS
TABLES
THERMODYNAMICS
TRACER TECHNIQUES