INVESTIGATION OF THE ADRENAL CORTEX FUNCTION IN WHOLE BODY IRRADIATION AFTER APPLICATION OF PERISTON-N

Journal Article · Sun Feb 01 04:00:00 EST 1959 · Strahlentherapie (West Germany)

OSTI ID:4263759

Lohr, E

In mice and rats the excretion of 17-ketosteroids and 17-ketogens was used as a test of the function of the adrenal cortex. After whole-body irradiation of 1,000 r the animals died within 3 to 4 days. A primary increase of the 17-ketosteroids was observed in almost every animal within 24 hours after irradiation. Administration of Periston-N after irradiation has no significant effect on the survival time, but a decrease of the excretion of 17-ketosteroids within 24 hours was observed. The additional administration of theophylline has no effect on survival time and excretion of the hormones. After injection of urine of irradiated rats an increase of the excretion of ketogens was observed. No real radiation sickness occurred in animals after the injection of urine of irradiated animals treated with Perision-N, which is in contrast to previous observations. All animals survived a 30-day period. An antitoxic effect and effects for radiation protection of Periston-N could not be observed but an effect on the course of the radiation sickness is presumable. (auth)

• Research Organization: Max-Planck-Institut fur Biophysik, Frankfurt am Main
• NSA Number: NSA-13-009661
• OSTI ID: 4263759
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 108; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ADRENAL GLANDS
ALKALOIDS
BIOLOGY AND MEDICINE
BODY
DRUGS
HORMONES
KETOSTEROIDS
METABOLISM
MICE
ORGANIC NITROGEN COMPOUNDS
POLYVINYLS
PVP
PYRROLIDONES
RADIATION DOSES
RADIATION PROTECTION
RADIATION SICKNESS
RATS
STEROIDS
SURVIVAL TIME
THEOPHYLLINE
URINE
X RADIATION