EFFECT OF X-IRRADIATION ON HUMAN ERYTHROCYTE METABOLISM. Annual Report for August 1, 1957-July 31, 1958
Technical Report
·
OSTI ID:4261102
BS>Studies of the metabolism of human erythrocytes stored under standard blood bank conditions and x irradiated in vitro with lethal and super-lethal doses were carricd out. These studies indicate that erythrocytes stored in ACD solution have slightly lower levels of respiration than unstored cells, but show no progressivc changes in respiration with storage. A comparison of unirradiated and irradiated samples indicated that x irradiation caused slight increases in the respiration of stored erythrocyhes, but 700 r and 1400 r did not cause significant damage to the "Blood Bank" stored cells. Hemolysis studics indicated that freshly drawn and 48-hour-stored red cells are not damaged by radiation doses up to 700 r. A kinetic analysis of red cell glycolysis indicated that maximum velocities were approximately equal at normal blood values of glucose, but at higher or lower glucose levels inhibition of glycolysis was cvident following 700 r. (auth)
- Research Organization:
- Ohio State Univ. Research Foundation, Columbus
- NSA Number:
- NSA-13-014130
- OSTI ID:
- 4261102
- Report Number(s):
- AD-200543
- Country of Publication:
- United States
- Language:
- English
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