THE EFFECT OF SINGLE PROLONGED ADMINISTRATION OF RADIOSTRONTIUM INTO THE GASTROINTESTINAL TRACT OF A RAT'S ORGANISM (in Russian)
The biological effects of Sr/sup 89/ and Sr/sup 90/ and their mixtures in single and daily (for 100 days) introduction into the gastrointestinal tract in doses exceeding the highest permissible by 1 to 3 times were studied. The specific activity exceeding the maximum permissible by one (7.3 mc Sr/sup 90/, 30 mc/sup 89/, 30 mc Sr/sup 89.90/) do not change the life span of animals. However, they provoke a moderate transient leukopenia. Acute radiation sickness, developing upon single administration of 1500 mc of Sr/sup 89/, 360 mc of Sr/sup 90/ into the gastrointestinal tract, runs a course resembling panmyelonpthisis with an acutely marked hemorrhagic syndrome and affection of the intestine (acute enteritis). In subacute radiation sickness, developing as a result of peroral introduction of strontium isotopes (30to 300 mc of Sr/sup 90/, Sr/sup 89.90/, 73 mc of Sr/sup 90/) the following is characteristic: inhibition of bone marrow hematopoiesis coupled with marked pathological regeneration of reticuloendothelium of stroma, leukopenia, moderate terminal erythropenia, intensive ectopic spleen hematopoiesis, secondary degenerative changes of parenchymatous organs, local changes of the gastrointestinal tract (gingivites, ostites, periostites, of jaws, solitary ulcers in the large intestine). Leukemias, and osteosarcomas develop when strontium is introduced into the organism in quantities exceeding the maximum permissible by the order of two or three. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-13-014182
- OSTI ID:
- 4254890
- Journal Information:
- Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 4, No. 2; ISSN MERAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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Related Subjects
BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
BONES
CANCER
CARCINOGENESIS
ENTERITIS
ERYTHROCYTES
HEMORRHAGE
INTESTINE
LEUCOCYTES
LEUKEMIA
OSTEOSARCOMAS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
SPLEEN
STOMACH
STRONTIUM 89
STRONTIUM 90
SURVIVAL TIME
TISSUES
ULCERS
VARIATIONS