Response of Megakaryocytes of the ‘August’ Rat to X-irradiation
Methods of evaluating the numbers of megakaryocytes of the "August" rat are described. As a result of these studies, it is concluded that irradiation causes a block in cell-divisions in the stem-cell preceding the megakaryoblast, and results in a fall in numbers of megakaryocytes, and consequently of platelets. A similar conclusion was reached by Zajicek and Zeuthen (1956). Megakaryocyte numbers are readily reduced by x rays, a dose of 80 r effecting a reduction of 50 per cent within 7 days of irradiation. Studies on partially shielded animals demonstrated a pronounced megakaryocyte hyperplasia in the shielded sites. Recovery in the irradiated areas was found to commence earlier than after wholebody radiation. These results throw some light on the mechanisms by which platelet levels are maintained after partial-body irradiation.
- Research Organization:
- Royal Cancer Hospital, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-13-014175
- OSTI ID:
- 4247374
- Journal Information:
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 2 Vol. 1; ISSN 0020-7616
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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