Probable essential thrombocythemia in a dog

Journal Article · Fri Mar 31 23:00:00 EST 1989 · J. Vet. Intern. Med.; (United States)

DOI:https://doi.org/10.1111/j.1939-1676.1989.tb03083.x· OSTI ID:5877703

Hopper, P E; Mandell, C P; Turrel, J M; Jain, N C; Tablin, F; Zinkl, J G

Essential thrombocythemia (ET), in an 11-year-old dog was characterized by persistently high platelet counts range, 4.19 X 10(6)/microliters to 4.95 X 10(6)/microliters, abnormal platelet morphology, marked megakaryocytic hyperplasia in the bone marrow, absence of circulating megakaryoblasts, and history of splenomegaly and gastrointestinal bleeding. Increased numbers of megakaryocytes and megakaryoblasts (15% to 20%) in the bone marrow were confirmed by a positive acetylcholinesterase reaction. Another significant finding was the presence of a basophilia in blood (4,836/microliters) and bone marrow. The marked persistent thrombocytosis, absence of reactive (secondary) thrombocytosis, abnormal platelet morphology, and quantitative and qualitative changes in the megakaryocytic series in the bone marrow suggested the presence of a myeloproliferative disease. Cytochemical and ultrastructural findings aided in the diagnosis of ET. The dog was treated with radiophosphorus. The results was a rapid decline in the numbers of megakaryoblasts and megakaryocytes in the bone marrow and platelets and basophils in the peripheral blood. The dog died unexpectedly of acute necrotizing pancreatitis and diabetes mellitus before a complete remission was achieved.

• Research Organization: Univ. of California, Davis (USA)
• OSTI ID: 5877703
• Journal Information: J. Vet. Intern. Med.; (United States), Journal Name: J. Vet. Intern. Med.; (United States) Vol. 3:2; ISSN JVIME
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COUNT
BLOOD PLATELETS
BODY FLUIDS
BONE MARROW CELLS
CARBOXYLESTERASES
CHOLINESTERASE
CONNECTIVE TISSUE CELLS
DISEASES
DOGS
ELECTRON MICROSCOPY
ENZYMES
ESTERASES
HYDROLASES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MICROSCOPY
PATHOGENESIS
PHOSPHORUS ISOTOPES
SOMATIC CELLS
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS
VASCULAR DISEASES
VERTEBRATES