STUDY OF IODINE METABOLISM BY AN "ISOTOPIC EQUILIBRIUM" METHOD: DETERMINATION OF THE IODISED FRACTIONS IN DIFFERENT PHYSIOLOGICAL STATES

Journal Article · Tue Jan 01 04:00:00 EST 1957 · Compt. rend. soc. biol.

OSTI ID:4247233

Simon, Cl; Morel, F

By means of a prolonged administration, over a period of several weeks, of a constant amount of iodie labelled with I/sup 131/ of known specific radioactivity, the stable iodine in the organism can be progressively replaced by the labelled iodine administered; after 4 or 5 weeks isotopic equilibrium'' is effectively reached. From then on, by measuring the raditoactivity of the different iodized fractions of the plasma and the thyroid (after chemical separation in the presence of carriers), the absolute quantity of iodine contained in these fractions can be calculated. The total iodine, the iodide and the organic iodine of the plasma and thyroid were measured in rats by this method as a function of the iodide content of the diet, as well as under the influence of an antithyroid agent. (auth)

• Research Organization: Commissariat a l'Energie Atomique, Paris
• NSA Number: NSA-13-011568
• OSTI ID: 4247233
• Journal Information: Compt. rend. soc. biol., Journal Name: Compt. rend. soc. biol. Vol. Vol: 151
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

BIOLOGY AND MEDICINE
BLOOD PLASMA
DIET
DRUGS
IODIDES
IODINE
IODINE 131
LABELLED COMPOUNDS
METABOLISM
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RATS
THYROID