IMMUNOGENETIC STUDIES ON X-IRRADIATED MICE TREATED WITH HEMATOPOIETIC CELLS AND GRAFTED WITH TUMOR TISSUES

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4242907

Feldman, M; Yaffe, D

A study was made of the behavior of tumor grafts in the radiation chimera to analyze the immune reactivity of the donor's hematopoietlc cells and the influence on tumor cells of the radiation chimera. The regression of homografts of Sarcoma C10 and Sarcoma MC1M (of C3H origin) in irradiated C57BJ animals treated with C57BL cells and their progressive growth in irradiated animals treated with C57BE fetal hematopoietic cells gave evidence of the ability of donor cells to form transplantation immunity against foreign antigens, thus substantiating the graft versus host theory as the basis for homologous secondary disease. Tumor grafts produced metastases in irradiated animals, and irradiation and immunogenetic factors were shown to influence their development. The transplantation of Sarcoma SBL1 into various types of genetic chimeras was accompanied by immunogenetic changes in the tumor, which were manifested by the loss of strain specificity. The effect of total-body irradiation of the host and the absence of isologous C57BJ cells were shown to be the main factors determining this change. Their analysis provided definite indications that the acquired homotransplantability of SBLx sublines is basically a result of immunogenetic transformation induced by the host and not a result of selection of pre-existing compatible cell variants. (auth)

• Research Organization: Weizmann Inst. of Science, Rehovoth, Israel
• NSA Number: NSA-13-017708
• OSTI ID: 4242907
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 23; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIGENS
BIOLOGY
BIOLOGY AND MEDICINE
BLOOD FORMATION
BODY
CANCER
CHIMERAS
CYTOLOGY
DISEASES
FETUSES
GENETICS
IMMUNITY
MALFORMATIONS
METASTASES
MICE
RADIATION DOSES
RADIATION EFFECTS
SARCOMAS
TISSUES
TRANSPLANTS
TUMORS
VARIATIONS
X RADIATION