IMMUNOGENTIC STUDIES ON X-IRRADIATED MICE TREATED WITH HOMOLOGOUS HEMATOPOIETIC CELLS

Journal Article · Wed Oct 01 04:00:00 EDT 1958 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4286867

Feldman, M; Yaffe, D

ing place in x-irradiated mice treated with homologous hematopoietic cells. The results of experiments with hybrid combinations of hosts and donors suggest that the grafted cells react imnnunologically against the isoantigens of the irradiated recipient. The production of antiC3H agglutinins by the inoculated C57BL cells was demonstrated by the transfer of lymph nodes from the irradiated and treated C3H mice back to normal C57BL mice. The ''cytotoxic'' anti-host immune reaction responsible for the lethal ''secondary disease'' of homologously treated mice was demonstrated by the passive transfer of tramsplantation immunity produced by the isoantigens of the recipient. Bone marrow from irradiated C3H mice treated with C57BL cells conferred on other irradiated C3H mice a much shorter survival time than normal C57BL cells. It is concluded that the cells from the C57BL-treated C3H donors were immunologically activated by the primary C3H hosts and killed the secondary C3H hosts through an immunologically secondary response. Thc mortality of nvice treated with mixed embryonic isologous and adult homologous cells indicates that even if, theoretically, a delayed antigraft response is feasible, the graft antihost response has a domin:int role in the immunogenetic incompatibility. An attempt to overcome this incompatibility was made by injecting irradiated C3H mice with fetal C57BL liver cells. The increased survival time obtained in this experiment may suggest a method for the application of the principles of biological protection to animals of genetically heterogeneous populations. (auth)

• Research Organization: Weizmann Inst. of Science, Rehovoth, Israel
• NSA Number: NSA-13-001068
• OSTI ID: 4286867
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 21; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
AGGLUTININS
ALLERGY
ANIMAL CELLS
ANTIBODIES
ANTIGENS
BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
DISEASES
EMBRYOS
GENETICS
IMMUNITY
IRRADIATION
LYMPH NODES
LYMPH SYSTEM
MAN
MEDICINE
MICE
NASOPHARYNX
POPULATIONS
RADIATION EFFECTS
RADIATION PROTECTION
RADIOTHERAPY
SURVIVAL TIME
TISSUES
TOXICITY
TRANSPLANTS
TUMORS
X RADIATION