IMMUNOGENETIC CHANGES INDUCED IN TUMORS GROWN IN RADIATION CHIMERAS

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4234815

Yaffe, D; Feldman, M

An analysis was made of the immunogenetic properties of SBL,x tumor lines that had acquired homotransplantability by growing in radiation chimeras. This study mainly concerned the nature of the induced change and the mechanism of homotransplantability acquired. The SBLx tumors had lost the original antigenicity of SBL1, and the homotransplantability of SBLx was thus based on its inability to elicit an immune response. SBLx homografts, however, were found to be highly susceptible to transplantation immunity. Thus, the low antigenicity of the tumor cells was not due to the loss of the H antigens, but was attributed to a low rate of antigen emission. The analysis of these properties provided evidence that the change of SBL1 to SBLx involved a genetic transformation induced by the conditions that prevailed in the radiation chimeras. The acquired homotransplantability was found to be a reversible process. Transplantation of SBLx tumors back into C57BL or into (C3H x C57BL)F/sub 1/ mice resulted in a complete loss of homotransplantability. The more existence of the isologous C57BL antigens in the host was sufficient to produce this reversed change, and the SBLxB1 tumors thus formed regained the original antigenicity of SBL1. This reversed process took place only if the SBLx tumor was transplanted to hosts of foreign strains following 9 to 16 days of growth in C57BL mice. Prolonged growth of the tumor in C57BJ mice did not result in the loss of strain specificity. The significance of these data in relation to the possible mechanism of the reversible change is discussed. (auth)

• Research Organization: Weizmann Inst. of Science, Rehovoth, Israel
• NSA Number: NSA-13-017709
• OSTI ID: 4234815
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 23; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIGENS
BIOLOGY
BIOLOGY AND MEDICINE
CANCER
CHIMERAS
CYTOLOGY
GENETICS
IMMUNITY
MALFORMATIONS
MICE
RADIATION EFFECTS
SARCOMAS
TRANSPLANTS
TUMORS
VARIATIONS