THE METABOLISM AND TOXICOLOGY OF STRONTIUM-90 IN THE RAT. RATIONALE, EXPERIMENTAL PROCEDURES, PILOT EXPERIMENTS
In preparation for studies of the toxicity of strontium-90 in the rat, procedures have been established for the administration of Sr/sup 90/ solutions by imbibition to rats under physiological conditions for periods of time, ranging from 10 days to 30 days. The conditions of exposure and dosages used were designed to simulate those under which human populations might be exposed as a result of nuclear accidents or acts of war. The body retention of Sr/sup 90/ under laboratory conditions ranged from 1% of the administered dose in old rats to about 5% in very young rats. The metabolic removal of Sr/sup 90/ from young adult rats, measured 40 days after dosing, was about 0.01% of the body burden per duy. A simplified method for monitoring the body burdens of experimental animals in vivo by counting bremsstrahlung with a sodium iodide crystal is described. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- NSA Number:
- NSA-14-001334
- OSTI ID:
- 4239502
- Report Number(s):
- UR-424
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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