STRONTIUM-90 TOXICITY IN RAT EMBRYO
Gestating rats wete injected intravenously with doses of 191 or 382 mu C of Sr/sup 90/ on the 2nd, 10th, and 17th days postconception. Examination of implantation sites on the 20th day post-conception showed that the injection of Sr/sup 90/ on day 2 post-conception caused a significant increase in fetal mortality and growth retardation, greater in degree after the larger dose, and that injection of Sr/sup 90/ on the 10th postconception day retarded growth and increased mortality (slightly) only after the larger dose. The maternal hematocrit was lowered significantly at both dose levels following Sr/sup 90/ injection on either the 2nd or 10th day postconception, and this effect was greater in those injected on day 2 post-conception. The hematocrit of fetuses of Sr-injected rats was decreased slightly, but not significantly. The injection of either 191 or 382 mu C of Sr/sup 90/ on day 17 post-conception did not cause any apparent differences from control values in body weights and numbers of viable offspring per litter at parturition. There was an increased daily cumulative mortality in offspring of Sr-treated rats during the first week of life, but this was no longer evident by one month of age. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- NSA Number:
- NSA-18-011575
- OSTI ID:
- 4075580
- Report Number(s):
- UR-639
- Country of Publication:
- United States
- Language:
- English
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