Biochemical Changes in Beta-Irradiated Epidermis of Guinea Pigs

Journal Article · Sun Nov 01 04:00:00 EST 1959 · Radiation Research

DOI:https://doi.org/10.2307/3570748· OSTI ID:4239090

Tabachnick, Joseph; Weiss, Charles

An investigation was made of the concentrations of water, total protein, total free amino acids, ammonia, urocanic acid, deaminated histidine, DNA, and RNA in epidermis during the latent and acute stages and the healing period after beta irradiation. Histologic changes observed are described. Data are tabulated on biochemical changes. Eighteen free amino acids were isolated from untreated and irradiated epidermis and their pattern was shown to be unaffected by radiation. Since increases in concentrations of total free amino acids and urocanic acid of epidermis occur in spite of the fact that the sebaceous glands and apocrine sweat glands have been destroyed by irradiation, it is tentatively concluded that these compounds do not originate to any significant degree from the organelles in the dermis.

• Research Organization: Albert Einstein Medical Center, Philadelphia
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-001391
• OSTI ID: 4239090
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 5 Vol. 11; ISSN 0033-7587
• Publisher: Radiation Research Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACRYLIC ACID
AMINO ACIDS
AMMONIA
BETA PARTICLES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CYTOLOGY
GLANDS
GUINEA PIGS
HISTIDINE
IMIDAZOLES
NUCLEIC ACIDS
ORGANIC ACIDS
PROTEINS
QUANTITY RATIO
RADIATION INJURIES
REGENERATION
RIBONUCLEIC ACID
SKIN
UROCANIC ACID
WATER