Late Effects of Internally Deposited Radioisotopes in Laboratory Animals

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Radiation Research, Supplement

DOI:https://doi.org/10.2307/3583644· OSTI ID:4235349

Finkel, Miriam P.

Radiotoacity studies with internally deposited isotopes are complicated by the facts that the total dose and the dose rate cannot be controlled and cannot be adequately measured because they vary with time and space. Insoluble materials introduced into the body remain at the sits of adminigtration, whereas soluble materials are distributed in accordance with their chemical characteristics. The late effects of moderate and low doses of radioisotopes are reduction in life span and induction of tumors. These responses are influenced by the type and energy of the radiations, by the amount of material that remains in the body, and by the location of the retained material. Comparisons of the effects of intravenous injections of Ra/sup 226/, Pu/sup 239/, U/sup 233/ Po/sup 210/, Sr/sup 90/ and Ca/sup 45/ in mice can contribute to an understanding of the many factors involved in the long-term effects of internal emitters. On an injected microcurie basis, the alpha -particle emitters are more toxic than the beta -particle emitters. Radium is the least effective of the former in reducing life span, and its potency as a skeletal carcinogen is less than that of Pu/sup 239/ but slightly greater than that of U/ sup 233/. The differences in effectiveness between injected microcurie doses of Sr/sup 90/ and Ca/sup 45/ are largely due to differences in beta -ray energy. In addition to the induction of soft tissue tumors by Po/sup 210/ and the induction of malignant bone tumors by the other isotopes, all influenced the tumors of the blood-forming tissues. Since these neoplasms seemed to be affected by levels of Sr/sup 90/ that produced no change in life span or in number of osteogenic sarcomas, and since they show certain similarities to the human leukemias, they are an important subject for further study.

• Research Organization: Argonne National Lab., Lemont, Ill.
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-015906
• OSTI ID: 4235349
• Journal Information: Radiation Research, Supplement, Journal Name: Radiation Research, Supplement Vol. 1; ISSN 0485-8611
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALPHA DECAY-- BETA DECAY-- BLOOD FORMATION-- BONES-- CALCIUM 45-- CARCINOGENESIS-- MICE-- PLUTONIUM 239-- POLONIUM 210-- RADIATION EFFECTS-- RADIUM 226-- SARCOMAS-- STRONTIUM 90-- SURVIVAL TIME-- TISSUES-- TOXICITY-- TUMORS-- URANIUM 233
BODY-- CARCINOGENESIS-- DISTRIBUTION-- RADIATION DOSES- - RADIATION INJURIES-- RADIOISOTOPES-- SOLUBILITY-- SURVIVAL TIME-- TISSUES-- TOXICITY-- VARIATIONS