THE CHANGE OF PHAGOCYTOSIS IN THE LUNGS IN RADIATION SICKNESS

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4234661

Ivanov, A E; Kurshakova, N N

The state of pulmonary phagocytes in rabbits subjected to irradiation in the dose of 800 r was studied. The phagocytosis was studied in the imprints and histological preparations of the lungs by introduction into the trachea of trypan blue during the life of the animals. The activity of oxidative enzymes (succindehydrase and cytochrome oxidase) was determined in the pulmonary macrophages with histochemical methods. The investigations were conducted in dynamics, starting from the 6th hour up to the 20th day following irradiation. It is shown that in radiation sickness there occurs a considerable decrease of phagocytic properties of pulmonary macrophages. The changes are of a phasic character, corresponding with the stages of radiation sickness development as a whole. The decrease of phagocytosis occurs as the result of diminution of the absolute number of macrophages and the loss of the ability to engulf foreign particles, as well as due to the disturbance of processes of intracellular digestion, which is evidenced by the drop of the activity of oxidative enzymes. Inhibition of phagocytosis is, apparently, one of the principal causes of permeability of the lung barrier and the peculiarity of pneumonic changes in conditions of radiation sickness. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-13-017721
• OSTI ID: 4234661
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 4, No. 7; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ANIMAL CELLS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CYTOCHROME OXIDASE
CYTOLOGY
DIFFUSION
DYES
ENZYMES
LUNGS
METABOLISM
OXIDATION
PHAGOCYTES
PHAGOCYTOSIS
PHYSIOLOGY
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION SICKNESS
TRYPAN BLUE
VARIATIONS