FAILURE OF RADIOIODINE TO INDUCE THYROID CANCER IN THE RAT

Journal Article · Tue Sep 01 04:00:00 EDT 1959 · Cancer Research

OSTI ID:4222242

Field, J B; McCammon, C J; Valentine, R J; Bernick, S; Orr, C; Starr, P

Of a group of 751 young Long-Evans female rats, 392 were given 275 mu c I/sup 131/, and 48 were given 75 mu c I/sup 131/ subjected to a three-quarter thyroidectomy. All were maintained for a lengthy period of up to 24 to 33 months on a low-iodine goitrogenic regimen. The rats were divided into groups and given dietary supplements or parenteral therapy for the duration of the study. Comparable rats not treated with I/sup 131/ were matched as controls, and another group of rats was maintained for an equal period of time on an iodine-adequate diet. The thyroid Bland of most of the 330 autopsied rats treated with I/sup 131/ was partially to almost completely destroyed by the effects of irradiation. Only one rat exhibited a malignancy, and this appeared to be a lymphoma. Nodular or hyperplastic change of the thyroid was rarely encountered. By contrast, 33% of rats given methylthiouracil developed carcinomas of the thyroid gland, and an additional 63% showed marked nodular changes in the gland. The administration of throxin reduced the incidence of thyroid cancer in rats treated with methylthiouracil from 33 to 4%. It wss not possible to confirm the reports of others that the administration of radioiodine to young adult rats produces a siguificant incidence of malignant change of the thyroid gland. (auth)

• Research Organization: Univ. of Southern California, Los Angeles; Los Angeles County General Hospital, Los Angeles
• NSA Number: NSA-13-020817
• OSTI ID: 4222242
• Journal Information: Cancer Research, Journal Name: Cancer Research Vol. Vol: 19
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
CANCER
CARCINOGENESIS
DIET
DISEASES
DRUGS
HETEROCYCLICS
HORMONES
IODINE 131
IRRADIATION
KETONES
LYMPH SYSTEM
MEDICINE
METHYL RADICALS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PYRIMIDINES
RADIATION INJURIES
RADIOTHERAPY
RATS
STANDARDS
SURGERY
TESTING
THYROID
THYROXINE
TUMORS
URACILS
VARIATIONS