COMPARISON OF IODINE-124 AND IODINE-131 IN INHIBITION OF GOITROGENESIS IN THE RAT
The inhibftfon of goftrogenesfs in rat thyroids by iodiae was studied for I/sup 124/ and I/sup 131/, and the results were compaced. The method used was to measure the goiters produced fn .response to a 10-day course of methylthiouracil consumed 3 to 4 months after a single iodine dose. The I/sup 124/ used was contaminated with other iodine isotopes with the ratio I/sup 123//I/ sup 124//I/sup 126/ - I 0/2 0/0 17 The average thyrofd weight o f the controls (no iodine or methylthiouracil) was 23.6 mg and that of those treated with methylthiouracil but no iodine was 48.9 mg; the results obtained with rats treated with both are expressed as percentage inhibition wfth 25-mg control thyroid and 50-mg goitrogen thyroid as basis. Both 29.5- mu c I/sup 131/ and 53- mu c I/sup 124/ showed 60% inhibitfon. Since it is calculated that 2.5- mu c I/ sup 124/ will give the same average radiation dose to the gland as 1- mu c I/sup 124/, I/sup 124/ is slightly more effective than I/sup 131/ for equivalent damage. (D.L.C.)
- Research Organization:
- Postgraduate Medical School, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-022781
- OSTI ID:
- 4155565
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 187
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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