EFFECT OF WHOLE-BODY X-IRRADIATION ON THE ADRENAL MEDULLA AND THE HORMONES ADRENALINE AND NORADRENALINE
Journal Article
·
· American Journal of Physiology (U.S.)
OSTI ID:4218152
The purpose of these experiments was to determine the effect of x irradiation on the adrenaline and noradrenaline content of the adrenal gland and on the biosynthesis of these hormones. Rats, rabbits, and cats were irradiated. Adrenal glands were removed at various times post irradiation and assayed for adrenaline and noradrenaline. Further, irradiated adrenal slices were incubated with labeled tyrosine and labeled methionine and the effect of irradiation upon the biosynthesis of adrenaline and noradrenaline determined. The results of these experiments show that x irradiation (1770 r) does not decrease the biosynthesis of adrenaline and noradrenaline. However, whole-body irradiation does cause the adrenaline and noradrenaline content of the adrenal gland to decline; the adrenal gland content ultimately returns to normal. In view of these findings, it would seem that x irradiation represents another form of stress in which the physiological demand for adrenaline and noradrenaline is so great that the adrenal gland is partially or completely depleted of its adrenaline-noradrenaline storage. (auth)
- Research Organization:
- Memorial Research Center and Hospital, Knoxville, Tenn.
- NSA Number:
- NSA-14-005040
- OSTI ID:
- 4218152
- Journal Information:
- American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 197; ISSN AJPHA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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