Suppression of the oxidative phosphorylation after in vitro irradiation of isolated mitochondria in dependence on the dose and concentration

Journal Article · Tue Mar 01 04:00:00 EST 1960 · RoeFo - Fortschritte auf dem Gebiete der Roentgenstrahlen und der bildgebenden Verfahren

DOI:https://doi.org/10.1055/s-0029-1226524· OSTI ID:4206984

Fritz-Niggli, Hedi; Bührer, Gérard

Irradiation of isolated mitochondria derived from rat livers and placed in an isotonic mannitol solution interferes with oxidative phosphorylation with alpha -ketoglutarate, beta -oxybutyrate, or succinate serving as hydrogen donors. The degree of interference depends on the dose. The degree of interference depends on the concentration of the irradiated suspension of mitochondria, increasing with decreasing concentration of the suspension. A possible role of vitamin K in the mechanism of irradiation induced interference of oxidative phosphorylation is discussed.

• Research Organization: Kantonsspitals, Zurich
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-010352
• OSTI ID: 4206984
• Journal Information: RoeFo - Fortschritte auf dem Gebiete der Roentgenstrahlen und der bildgebenden Verfahren, Journal Name: RoeFo - Fortschritte auf dem Gebiete der Roentgenstrahlen und der bildgebenden Verfahren Journal Issue: 03 Vol. 92; ISSN 1438-9029
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
BIOCHEMISTRY
CHEMICAL REACTIONS
HYDROGEN
IRRADIATION
LIVER
MANNITOL
METABOLISM
MITOCHONDRIA
ORGANIC ACIDS
PHOSPHORYLATION
QUANTITY RATIO
RADIATION DOSES
RATS
SOLUTIONS
SUCCINIC ACID
SUGARS
VITAMIN K
VITAMINS