CHEMICAL PROTECTION OF VERTEBRATES AGAINST IONIZING RADIATIONS (in Italian)
There are many substances of very varied chemical structure which protect mammals and other living organisms against x or gamma irradiation. That some change occurs in physicochemical events, early after energy absorption, is the only logical explanation of the protection afforded by the presence of cysteamine or related compounds. Certain physicochemical mechanisms may apply to anoxic and aerated systems, some are restricted to aerated systems. Some substances, lixe cysteamine, protect against both indirect action involving free radicals and direct action by energy transfer. There is no reason to reject the hypothesis that several physicochemical mechanisms of protection may be simultaneous and synergistic. A revised interpretation is proposed for mammalian protection by the cysteamine type of protector. Some protectors, like histamine, adrenaline, and p-aminopropiophenone, probably act in the mammals mainly by reducing the O/sub 2/ tension in the tissues. Fluoroacetate and some other substances seem to protect by the induction of slow biochemical changes. (auth)
- Research Organization:
- Universite, Liege
- NSA Number:
- NSA-14-017763
- OSTI ID:
- 4199145
- Journal Information:
- Radiobiol. Latina, Journal Name: Radiobiol. Latina Vol. Vol: 2
- Country of Publication:
- Country unknown/Code not available
- Language:
- Italian
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Related Subjects
ACETATES
ADRENAL GLANDS
ADRENALINE
AMINO ACIDS
ANIMALS
BIOLOGY AND MEDICINE
CHEMICAL REACTIONS
CHEMICALS
CYSTEAMINE
ENERGY
FREE RADICALS
GAMMA RADIATION
HISTAMINE
HORMONES
KETONES
MEA
ORGANIC FLUORINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
PAPP
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATION PROTECTION
RADIOBIOLOGY
REACTION KINETICS
REDUCTION
X RADIATION