STUDIES ON THE PATHOGENESIS OF NEOPLASMS BY IONIZING RADIATION. II. NEOPLASMS OF ENDOCRINE ORGANS

Journal Article · Tue Dec 01 04:00:00 EST 1959 · Cancer Research

OSTI ID:4196264

Haran-Ghera, N; Furth, J; Buffett, R F; Yokoro, K

ABS>In an analysis of the pathogenesis of neoplasms of endocrine organs occurring in mice exposed to an experimental atomic detonation, groups of 1O9 to 140 mice were irradiated with fission neutrons or x rays over the entire body. Some groups were partially shielded; others were subjected to endocrine stresses. Total-body neutron exposure caused thyroid tumors in 3.4 and 7.3 per cent of mice; none was found in total-body x-rayed mice. Thyroid tumors were found in irradiated adrenalectomized and gonadectomized mice; none was found in unirradiated, bilaterally adrenalectomized animals. A high incidence of thyroid tumors occurred in head-neck-irradiated mice. Both adrenal cortical adenomas and chromaffinomas were induced by total-body neutron irradiation and none was seen in similarly x-rayed mice and unirradiated controls, The incidence of ovarian tumors in the total-body- neutron or x-radiated groups was not diminished by sheilding the upper half of the body. The ovarian tumor incidence was not appreciablly raised by isolited head and neck irradiation. It is concluded that neutrons have a high relative biological effectiveness in relation to x ray or gamma rays for thyroid and adrenal tumor induction. With respect to ovarian tumorigenesis, it is postulated, on the basis of present data and those of earlier investigators, that the eostatic forces with resultant sustained increase in gonadotropins. (auth)

• Research Organization: Children's Cancer Research Foundation, Boston; Harvard Medical School, Boston; and New England Deaconess Hospital, Boston
• NSA Number: NSA-14-004228
• OSTI ID: 4196264
• Journal Information: Cancer Research, Journal Name: Cancer Research Vol. Vol: 19
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADENOMAS
ADRENAL GLANDS
ADRENALECTOMY
BIOLOGY
BIOLOGY AND MEDICINE
BODY
BRAIN
CANCER
CARCINOGENESIS
CONTROL SYSTEMS
FISSION
GAMMA RADIATION
GONADS
HORMONES
MICE
NEUTRONS
NUCLEAR EXPLOSIONS
OVARIES
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RBE
SHIELDING
SURGERY
TESTING
THYROID
TUMORS
X RADIATION