CHANGES IN HEMOPOIESIS IN PATIENTS WITH THYROTOXICOSIS UNDER TREATMENT WITH RADIOACTIVE IODINE

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Problems Hematol. Blood Transfusion (U.S.S.R.) (English Translation)

OSTI ID:4194425

Kafafova, D D

The most characteristic changes in the blood of patients with thyrotoxicosis are leukopenia with a relative lymphocytosis or monocytosis, and in severe forms of the disease anemia of hypochromic type. After administration of 2 to 11 mc of iodine-131 a slight depression of leukopoiesis is observed, with a plasma cell and reticulum cell reaction. The white cell count of the peripheral blood falls temporarily and is restored to the initial level after 2 months. Return to normal of the white cell count with an initial leukopenia begins after disappearance or considerable alleviation of the signs of the thyrotoxicosis after 3 to 8 months. No disturbance of erythropoiesis nor thrombocytopoiesis is observed. The thrombocytopenia which sometimes is present is not accompanied by hemorrhages. The functional changes in the blood are transient in character. An initial leukopenia is no contraindication to iodine- 131 treatment of thyrotoxicosis. The fluorescent method of microscopy enables histochemical changes to be detected in the blood cells much sooner than by the usual morphological methods. (auth)

• Research Organization: Central Postgraduate Medical Inst., USSR
• NSA Number: NSA-14-012493
• OSTI ID: 4194425
• Journal Information: Problems Hematol. Blood Transfusion (U.S.S.R.) (English Translation), Journal Name: Problems Hematol. Blood Transfusion (U.S.S.R.) (English Translation) Vol. Vol: 4, No. 8
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANEMIA
BIOLOGY AND MEDICINE
BLOOD CELLS
BLOOD FORMATION
CYTOLOGY
DISEASES
FLUORESCENCE
HEMORRHAGE
IODINE 131
LEUCOCYTES
LEUKEMIA
LYMPHOCYTES
MAN
MEDICINE
MICROSCOPY
PERFORMANCE
PLATELETS
RADIOTHERAPY
THYROID
VARIATIONS